John H. Klich

Spatially Tuned Localization of Interleukins and OX40 Agonists EnhancesSynergistic Anti-Tumor Immunity

This paper demonstrates that localized delivery of immunotherapeutic agents via hydrogel depots enhances synergistic anti-tumor immunity in mouse tumor models.

Sustained Delivery of a SARS-CoV-2 Subunit Vaccine in An Adjuvanted Hydrogel Depot Enhances Vaccine Responses in Nonhuman Primates

This study shows that sustained delivery of a SARS-CoV-2 subunit vaccine in an adjuvanted hydrogel depot improves antibody responses in nonhuman primates compared to bolus vaccination.

Structure-Property-Performance Engineering of Hydrogel Depots for Long-Acting Peptide Delivery

This paper develops a hydrogel depot system for long-acting peptide delivery, showing sustained release and improved therapeutic outcomes in rodents.

Gradient Multinozzle 3D Printing

The paper introduces GEM multinozzle printheads to accelerate ink formulation by enabling parallelized printing and combinatorial ink mixing for complex 3D structures.

A Transient Immunostimulatory Niche Synergizes Adoptive and Endogenous Immunity for Enhanced Tumor Control

This paper develops ACTIVATE, a hydrogel-based platform that enhances tumor control by synergizing adoptive and endogenous immunity through localized cytokine delivery and T-cell activation.

Generation of an inflammatory niche in an injectable hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines

This paper improves mRNA vaccine efficacy by creating an inflammatory immune niche via injectable hydrogel depots that recruit immune cells and enhance humoral responses.

Sustained exposure to multivalent antigen-decorated nanoparticles generates broad anti-coronavirus responses

This paper develops a multivalent liposomal hydrogel vaccine that generates broad and durable anti-coronavirus antibody responses in mice.