Author

Ben S. Ou

Stanford UniversityORCID 0000-0002-0539-5166Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Research Focus:drug response / drug discovery· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Organism:non-human primate· 1

Frequent Co-Authors

Eric Andrew AppeliD· 7 shared Jerry YaniD· 5 shared John H. KlichiD· 5 shared Julie BailletiD· 4 shared Noah EckmaniD· 4 shared Olivia M. SaouafiD· 4 shared Ye Eun SongiD· 4 shared Ashley UtziD· 3 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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7 shared papersBioengineering

Eric Andrew AppelORCID

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Spatially Tuned Localization of Interleukins and OX40 Agonists EnhancesSynergistic Anti-Tumor Immunity

John H. Klich, Anahita Nejatfard, Emily L. Meany, Ben S. Ou, Zuzanna D. Krawczyk, Julie Baillet, Eric Andrew Appel

This paper demonstrates that localized delivery of immunotherapeutic agents via hydrogel depots enhances synergistic anti-tumor immunity in mouse tumor models.

Cell Reports Medicine · Oct 1, 2026Peer-reviewedBioengineering

Sustained Delivery of a SARS-CoV-2 Subunit Vaccine in An Adjuvanted Hydrogel Depot Enhances Vaccine Responses in Nonhuman Primates

Ben S. Ou, Mengyun Hu, Jerry Yan, Jordan M. Santagata, Olivia M. Saouaf, Haleigh B. Eppler, Victor Lujan, Ye Eun Song, Alba Grifoni, John H. Klich, Alessandro Sette, Ashley Utz, Mehul S. Suthar, Noah Eckman, Yupeng Feng, , Eric Andrew Appel

This study shows that sustained delivery of a SARS-CoV-2 subunit vaccine in an adjuvanted hydrogel depot improves antibody responses in nonhuman primates compared to bolus vaccination.

bioRxiv · Jul 20, 2026 · PreprintBioengineering

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age-Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, Eric Andrew Appel

This study develops a hydrogel-based vaccine delivery system that enhances immune responses and reduces reactogenicity in aged mice compared to Shingrix.

Advanced Science · Jul 13, 2026Peer-reviewedImmunology

A Transient Immunostimulatory Niche Synergizes Adoptive and Endogenous Immunity for Enhanced Tumor Control

Anahita Nejatfard, John H. Klich, Noah Eckman, Sophia J. Bailey, Karine Gillard, Daniel Ramos Mejia, Ben S. Ou, Jerry Yan, John W. Hickey, Eric Andrew Appel

This paper develops ACTIVATE, a hydrogel-based platform that enhances tumor control by synergizing adoptive and endogenous immunity through localized cytokine delivery and T-cell activation.

bioRxiv · Aug 22, 2025 · PreprintImmunology

Generation of an inflammatory niche in an injectable hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines

Emily L. Meany, John H. Klich, Carolyn K. Jons, Tianyang Mao, Namit Chaudhary, Ashley Utz, Julie Baillet, Ye Eun Song, Olivia M. Saouaf, Ben S. Ou, Shoshana C. Williams, Noah Eckman, Darrell J. Irvine, Eric Andrew Appel

This paper improves mRNA vaccine efficacy by creating an inflammatory immune niche via injectable hydrogel depots that recruit immune cells and enhance humoral responses.

Science Advances · Apr 11, 2025Peer-reviewedBioengineering

Sustained vaccine exposure elicits more rapid, consistent, and broad humoral immune responses to multivalent influenza vaccines

Olivia M. Saouaf, Ben S. Ou, Ye Eun Song, Joshua J. Carter, Jerry Yan, Carolyn K. Jons, Christopher O. Barnes, Eric Andrew Appel

This study shows sustained delivery of multivalent influenza vaccines via polymer-nanoparticle hydrogels enhances rapid, consistent, and broad humoral immunity against homologous and heterologous strains.

Advanced Science · Mar 17, 2025Peer-reviewedBioengineering

Sustained exposure to multivalent antigen-decorated nanoparticles generates broad anti-coronavirus responses

Julie Baillet, John H. Klich, Ben S. Ou, Emily L. Meany, Jerry Yan, Theodora U. J. Bruun, Ashley Utz, Carolyn K. Jons, Sébastien Lecommandoux, Eric Andrew Appel

This paper develops a multivalent liposomal hydrogel vaccine that generates broad and durable anti-coronavirus antibody responses in mice.

Matter · Feb 25, 2025Peer-reviewedBioengineering