Discovery of a Selective, State-Independent Inhibitor of NaV1.7 by Modification of Guanidinium Toxins
Hassan Pajouhesh, Jacob T. Beckley, Anton Delwig, Holly S. Hajare, George Luu, Dennis Monteleone, Xiang Zhou, Joseph Ligutti, Shanti M. Amagasu, Bryan D. Moyer, David C. Yeomans, J. Du Bois, John V. Mulcahy
This paper describes the discovery of ST-2262, a selective NaV1.7 inhibitor with state-independent action, showing reduced pain sensitivity in non-human primates.
Scientific Reports · Sep 9, 2020Peer-reviewedNeuroscience