Author

David C. Yeomans

Stanford MedicineORCID 0000-0002-9389-8539Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:graph neural network· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Michael KlukinoviD· 2 shared Anton Delwig· 1 shared Bryan D. MoyeriD· 1 shared Cholawat PacharinsakiD· 1 shared Dennis MonteleoneiD· 1 shared George Luu· 1 shared Hassan Pajouhesh· 1 shared Holly S. HajareiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersSystems Biology

Michael KlukinovORCID

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3 papers

Recent·Most cited

Core Coefficient quantifies transcription-factor functional dominance for therapeutic target selection

Michael Klukinov, Rick Orr, William K Martin, David C. Yeomans, Julien Mamet

The paper introduces the Core Coefficient (CC) to quantify transcription factor functional dominance in regulatory networks, showing it can predict therapeutic target shifts in disease progression.

bioRxiv · Oct 28, 2026 · PreprintSystems Biology

Noninvasive Diagnostic Ultrasound-Guided Focused Ultrasound Enables Selective, Reversible Inhibition of Peripheral Nociceptive Fibers and Prevents Acute Pain

Namrata Sangwan, Lidia Mergelian, Michael Klukinov, Morteza Mohammadjavadi, Riya Navani, Cholawat Pacharinsak, Kim Butts Pauly, José G. Vilches-Moure, David C. Yeomans, Thomas A. Anderson

This paper demonstrates that noninvasive ultrasound-guided focused ultrasound can selectively and reversibly inhibit peripheral nociceptive fibers and prevent acute pain in a rat model.

bioRxiv · Jul 22, 2026 · PreprintNeuroscience

Discovery of a Selective, State-Independent Inhibitor of NaV1.7 by Modification of Guanidinium Toxins

Hassan Pajouhesh, Jacob T. Beckley, Anton Delwig, Holly S. Hajare, George Luu, Dennis Monteleone, Xiang Zhou, Joseph Ligutti, Shanti M. Amagasu, Bryan D. Moyer, David C. Yeomans, J. Du Bois, John V. Mulcahy

This paper describes the discovery of ST-2262, a selective NaV1.7 inhibitor with state-independent action, showing reduced pain sensitivity in non-human primates.

Scientific Reports · Sep 9, 2020Peer-reviewedNeuroscience