Holly S. Hajare

This paper develops a chemogenetic tool to selectively inhibit specific voltage-gated sodium channel subtypes with high precision and reversibility.

This paper identifies the structural basis for saxitoxin congener binding and neutralization by saxiphilins, showing how these proteins sequester toxins and reverse sodium channel blockage.

This paper describes the discovery of ST-2262, a selective NaV1.7 inhibitor with state-independent action, showing reduced pain sensitivity in non-human primates.