Inga Peter

Targeting Specific Kinase Substrates Rescues Increased Colitis Severity Induced by the Crohn's Disease-Linked LRRK2-N2081D Variant

This study investigates how the LRRK2-N2081D variant increases Crohn's disease risk by showing it causes more severe colitis and distinct RAB substrate phosphorylation compared to LRRK2-G2019S.

Maternal IBD-related antibodies are associated with early life gut inflammatory status and microbiota composition: insights from cord blood

The paper examines maternal IBD-related antibodies in cord blood and their associations with early life gut inflammation and microbiota composition.

Association of diet and inflammation with the vaginal microbiota of pregnant individuals with or without IBD

This study examines how diet and inflammation affect vaginal microbiota in pregnant individuals with or without IBD, finding that healthier diets correlate with higher Lactobacillus crispatus dominance.

Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14th century

The paper analyzes genome-wide data from medieval German Jews to show the Ashkenazi founder event occurred before the 14th century, with genetic heterogeneity not present in modern Ashkenazi Jews.

Sequencing of over 100,000 individuals identifies multiple genes and rare variants associated with Crohns disease susceptibility

The paper identifies ten new genes with coding variants linked to Crohn's disease risk using sequencing data from over 30,000 patients and 80,000 controls.

17q21.31 sub-haplotypes underlying H1-associated risk for Parkinsons disease are associated with LRRC37A/2 expression in astrocytes

The paper identifies three H1 sub-haplotypes at the 17q21.31 locus associated with Parkinson's disease risk and links them to LRRC37A/2 expression in astrocytes.

Novel ultra-rare exonic variants identified in a founder population implicate cadherins in schizophrenia

The paper identifies ultra-rare exonic variants in an Ashkenazi Jewish founder population, implicating cadherins in schizophrenia through recurrent mutations and altered purifying selection.

A study of Kibbutzim in Israel reveals risk factors for cardiometabolictraits and subtle population structure

The paper analyzes genetic and environmental factors in Israeli kibbutzim to identify cardiometabolic trait associations and population structure.

High-depth whole genome sequencing of a large population-specific reference panel: Enhancing sensitivity, accuracy, and imputation

The paper sequenced a population-specific reference panel at high depth to improve imputation accuracy and variant filtering in the Ashkenazi Jewish population.