Author

Ravindran Kumaran

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Organism:mouse· 1

Frequent Co-Authors

Mark CooksoniD· 3 shared Mike A. NallsiD· 3 shared Natalie LandeckiD· 3 shared Alexandra G. BeilinaiD· 2 shared Jesse Raphael GibbsiD· 2 shared Jinhui DingiD· 2 shared Juan Carlos TroncosoiD· 2 shared Luis Bonet‐PonceiD· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersNeuroscience

Mark CooksonORCID

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Author profile →

5 papers

Recent·Most cited

Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue

Jens O. Watzlawik, Xu Hou, Tyrique Richardson, Szymon L. Lewicki, Joanna S. Siuda, Zbigniew K. Wszołek, Casey N. Cook, Leonard Petrucelli, Michael A. Deture, Dennis W. Dickson, Odetta Antico, Miratul M. K. Muqit, Jordan B. Fishman, Karima Pirani, Ravindran Kumaran, , Wolfdieter Springer

This paper develops and characterizes novel phospho-ubiquitin antibodies to detect low levels of p-S65-Ub, a marker of mitochondrial damage, in cells and tissues.

Autophagy · May 27, 2024Peer-reviewedNeuroscience

Mutations in Auxilin cause parkinsonism via impaired clathrin-mediated trafficking at the Golgi apparatus and synapse

Dorien A. Roosen, Natalie Landeck, Luis Bonet‐Ponce, Jillian H. Kluss, Melissa M. Conti, Nathan Smith, Sara Sáez-Atiénzar, Jinhui Ding, Alexandra G. Beilina, Ravindran Kumaran, Alice Kaganovich, Johann du Hoffmann, Chad D. Williamson, David C. Gershlick, Luciana Sampieri, , Mark Cookson

This study identifies Auxilin mutations as a cause of Parkinson's disease by showing they impair clathrin-mediated trafficking at the Golgi and synapse, leading to neuropathological lesions.

bioRxiv · Sep 16, 2021 · PreprintNeuroscience

Mutations in the SPTLC1 gene are a cause of juvenile amyotrophic lateral sclerosis that may be amenable to serine supplementation

Janel O. Johnson, Ruth Chia, Danny E. Miller, Rong Li, Yevgeniya A. Abramzon, Ravindran Kumaran, Nada F. Alahmady, Faraz Faghri, Alan Edward Renton, Simon D. Topp, Hannah A. Pliner, Jesse Raphael Gibbs, Jinhui Ding, N. Smith, Natalie Landeck, , Bryan J. Traynor

The paper identifies de-novo SPTLC1 mutations in juvenile ALS patients and suggests serine supplementation may alleviate symptoms.

bioRxiv · Jun 29, 2020 · PreprintGenetics

Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

George R. Heaton, Natalie Landeck, Adamantios Mamais, Mike A. Nalls, Jonathon Nixon‐Abell, Ravindran Kumaran, Alexandra G. Beilina, Laura Pellegrini, Yan Li, Kirsten Harvey, Mark Cookson

The paper identifies LRRK2 as a regulator of clathrin-mediated endocytosis and links clathrin-trafficking pathways to Parkinson's disease risk.

Neurobiology of Disease · May 17, 2020Peer-reviewedMolecular Biology

Genetic modifiers of risk and age at onset in GBA associated Parkinson disease and Lewy body dementia

Cornelis Blauwendraat, Xylena Reed, Lynne Krohn, Karl Heilbron, Sara Bandrés‐Ciga, Manuela M. X. Tan, Jesse Raphael Gibbs, Dena G. Hernandez, Ravindran Kumaran, Rebekah G. Langston, Luis Bonet‐Ponce, Roy N. Alcalay, Sharon Hassin‐Baer, Lior Greenbaum, Hirotaka Iwaki, , Andrew Singleton

The paper identifies genetic modifiers of risk and age at onset in GBA-associated Parkinson disease and Lewy body dementia using large case-control datasets and genome-wide association studies.

Brain · Oct 23, 2019Peer-reviewedGenetics