Laura Pellegrini

This study uses single-cell RNA sequencing to track the maturation of human choroid plexus organoids and identifies a stage-dependent window of developmental plasticity.

The paper shows that slower axon growth in humans, driven by reduced calcium influx, leads to longer axon tracts through prolonged growth duration, with calcium dynamics regulating developmental timing.

This study develops protocols for generating mouse brain organoids that mimic in vivo neurodevelopment and function, showing they closely resemble in vivo models across multiple readouts.

This study uses brain organoids to show that male sex hormones increase excitatory neuron production in the human neocortex by enhancing progenitor proliferation and affecting chromatin remodeling.

This study shows SARS-CoV-2 infects choroid plexus epithelial cells in brain organoids, disrupts the blood-CSF barrier, and may contribute to neurological complications.

The paper identifies LRRK2 as a regulator of clathrin-mediated endocytosis and links clathrin-trafficking pathways to Parkinson's disease risk.