Jonathon Nixon‐Abell

PRISM is a plasmid-based reporter system for spectral microscopy that labels multiple organelles and provides quantitative metrics to study organelle network dynamics across cell types and conditions.

This study introduces ExVivo PhaseScan to generate high-resolution phase diagrams of physiological protein condensates and reveals how FUS mutations cause liquid-to-solid transitions in stress granules and nucleoli.

This study shows GLP-1R agonists improve mitochondrial health in beta-cells by forming a complex with VAPB and SPHKAP at ER-mitochondria MCSs, leading to mitochondrial remodelling and improved function.

The paper develops a multiplex reverse genetics platform to identify genetic modifiers of protein misfolding in neurodegenerative diseases and identifies DNAJB6 as a modifier of toxicity and solubility of ALS/FTD-linked RNA-binding proteins.

This paper introduces a CRISPR-based system called FAST-HDR that simplifies and accelerates the generation of knock-in cell lines for studying endogenous proteins.

The paper identifies LRRK2 as a regulator of clathrin-mediated endocytosis and links clathrin-trafficking pathways to Parkinson's disease risk.