SLAP controls mTORC2 integrity via UBE3C-mediated mLST8 ubiquitination to mediate its tumour suppressive function in colorectal cancer
Rudy Mevizou, Dana Naim, Florent Cauchois, Cécile Naudin, Georgia Greaves, Kevin Espie, Bastien Felipe, Valérie Simon, Yvan Boublik, Julie Nguyen, Serge Urbach, Serge Roche, Audrey Sirvent
This study identifies SLAP as a tumor suppressor in colorectal cancer that regulates mTORC2 integrity through UBE3C-mediated mLST8 ubiquitination, reducing mTORC2-AKT signaling.
bioRxiv · Mar 10, 2025 · PreprintCancer Biology