Author

Valérie Simon

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Audrey SirventiD· 2 shared Dana NaimiD· 2 shared Florent Cauchois· 2 shared Julie NguyeniD· 2 shared Kevin Espie· 2 shared Serge RocheiD· 2 shared Yvan Boublik· 2 shared Audrey Guesdon· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

Audrey SirventORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Slap restricts oncogenic Src-family kinase signaling to maintain colonic epithelial homeostasis

Dana Naim, Zouheir HOUHOU, Florent Cauchois, Kevin Espie, Valérie Simon, Yvan Boublik, Francina Langa Vives, Zeinab Homayed, Conception Paul, Morgan Maillard, Michael Hahne, Julie Pannequin, Julie Nguyen, Audrey Sirvent, Serge Roche

This study identifies SLAP as a tumor suppressor that limits SFK activity in colonic epithelial cells, preventing tumorigenesis and hyperproliferation.

eLife · Sep 8, 2026Peer-reviewedCell Biology

In vitro reconstitution defines the mechanistic basis of HSET motor activity regulation by IntraFlagellar Transport proteins

Audrey Guesdon, Valérie Simon, Ron Siaden-Ortega, Juliette van Dijk, Julien Marcoux, Bénédicte Delaval, Benjamin Vitre

This study uses an in vitro reconstitution system to show that IFT proteins enhance HSET kinesin processivity, promoting microtubule sliding and centrosome clustering.

Communications Biology · Apr 10, 2026Peer-reviewedCell Biology

SLAP controls mTORC2 integrity via UBE3C-mediated mLST8 ubiquitination to mediate its tumour suppressive function in colorectal cancer

Rudy Mevizou, Dana Naim, Florent Cauchois, Cécile Naudin, Georgia Greaves, Kevin Espie, Bastien Felipe, Valérie Simon, Yvan Boublik, Julie Nguyen, Serge Urbach, Serge Roche, Audrey Sirvent

This study identifies SLAP as a tumor suppressor in colorectal cancer that regulates mTORC2 integrity through UBE3C-mediated mLST8 ubiquitination, reducing mTORC2-AKT signaling.

bioRxiv · Mar 10, 2025 · PreprintCancer Biology