Author

Dana Naim

Centre National de la Recherche ScientifiqueORCID 0000-0002-4982-8381Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1 Assay:proteomics· 1

Frequent Co-Authors

Audrey SirventiD· 2 shared Florent Cauchois· 2 shared Julie NguyeniD· 2 shared Kevin Espie· 2 shared Serge RocheiD· 2 shared Valérie Simon· 2 shared Yvan Boublik· 2 shared Bastien Felipe· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCell Biology

Audrey SirventORCID

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2 papers

Recent·Most cited

Slap restricts oncogenic Src-family kinase signaling to maintain colonic epithelial homeostasis

Dana Naim, Zouheir HOUHOU, Florent Cauchois, Kevin Espie, Valérie Simon, Yvan Boublik, Francina Langa Vives, Zeinab Homayed, Conception Paul, Morgan Maillard, Michael Hahne, Julie Pannequin, Julie Nguyen, Audrey Sirvent, Serge Roche

This study identifies SLAP as a tumor suppressor that limits SFK activity in colonic epithelial cells, preventing tumorigenesis and hyperproliferation.

eLife · Sep 8, 2026Peer-reviewedCell Biology

SLAP controls mTORC2 integrity via UBE3C-mediated mLST8 ubiquitination to mediate its tumour suppressive function in colorectal cancer

Rudy Mevizou, Dana Naim, Florent Cauchois, Cécile Naudin, Georgia Greaves, Kevin Espie, Bastien Felipe, Valérie Simon, Yvan Boublik, Julie Nguyen, Serge Urbach, Serge Roche, Audrey Sirvent

This study identifies SLAP as a tumor suppressor in colorectal cancer that regulates mTORC2 integrity through UBE3C-mediated mLST8 ubiquitination, reducing mTORC2-AKT signaling.

bioRxiv · Mar 10, 2025 · PreprintCancer Biology