Author

Audrey Sirvent

Centre National de la Recherche ScientifiqueORCID 0000-0003-4555-6312Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1 Assay:proteomics· 1

Frequent Co-Authors

Serge RocheiD· 3 shared Yvan Boublik· 3 shared Dana NaimiD· 2 shared Florent Cauchois· 2 shared Julie NguyeniD· 2 shared Kevin Espie· 2 shared Valérie Simon· 2 shared Alejandro FernándeziD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCell Biology

Serge RocheORCID

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3 papers

Recent·Most cited

Cell BiologyeLifePeer-reviewedSep 8, 2026

Slap restricts oncogenic Src-family kinase signaling to maintain colonic epithelial homeostasis

Dana Naim, Zouheir HOUHOU, Florent Cauchois…·Serge Roche

This study identifies SLAP as a tumor suppressor that limits SFK activity in colonic epithelial cells, preventing tumorigenesis and hyperproliferation.

1 citation

mouseorganoid / primary culture

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Molecular BiologyLife Science AlliancePeer-reviewedMar 13, 2025

Lipid-driven SRC self-association modulates its transformation capacity

Irrem-Laareb Mohammad, Marina Inés Giannotti, Elise Fourgous…·Miquel Pons

The paper shows lipid-mediated self-association of Src kinase forms condensates on lipid bilayers, modulating its transforming capacity through a lysine cluster in the SH4 domain.

2 citations

humanexperimental assay

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Cancer BiologybioRxivPreprintMar 10, 2025

SLAP controls mTORC2 integrity via UBE3C-mediated mLST8 ubiquitination to mediate its tumour suppressive function in colorectal cancer

Rudy Mevizou, Dana Naim, Florent Cauchois…·Audrey Sirvent

This study identifies SLAP as a tumor suppressor in colorectal cancer that regulates mTORC2 integrity through UBE3C-mediated mLST8 ubiquitination, reducing mTORC2-AKT signaling.

DOI 10.1101/2025.03.10.642361

humanproteomics

𝕏 PostBluesky