Serge Urbach

This study identifies SNX5/6 as essential partners for NCOA7-AS antiviral activity against influenza A virus and reveals the structural basis for their interaction.

The paper establishes and characterizes IDH-mutant astrocytoma cell lines, revealing NOTCH-regulated plasticity between astrocyte-like and oligodendrocyte-like states.

The paper identifies RPAP3 and PIH1D1 as R2TP subunits and shows their role in assembling INO80, SRCAP, and TIP60 complexes through physical interactions and functional validation.

This study identifies endothelin signaling via EDNRB as a regulator of glioma cell proliferation and proneural-to-mesenchymal transition, with distinct receptor expression and functional roles in different tumor subtypes.

This study identifies how dengue virus uses mosquito Syntenin to package and secrete viral RNA into salivary exosomes, revealing a mechanism for viral RNA incorporation into extracellular vesicles.

This study characterizes the RNA and protein landscapes of mouse brain organoids, showing they closely resemble neonatal mouse brains and express synaptic proteins after three weeks of development.

The paper identifies co-translational interactions between R2TP and client proteins, revealing a mechanism called co-translational chaperone channeling that facilitates early assembly of protein complexes.

This study identifies YAP1's role in regulating oligodendrocyte-astrocyte fate switch and ependymal gene expression in adult spinal cord stem cells through in vitro experiments and multi-omic profiling.

The paper identifies new protein interactions of FANCA, revealing its roles in mRNA processes beyond DNA repair, and suggests potential therapeutic targets for Fanconi anemia.

This study identifies SLAP as a tumor suppressor in colorectal cancer that regulates mTORC2 integrity through UBE3C-mediated mLST8 ubiquitination, reducing mTORC2-AKT signaling.

This study identifies GNL3 as a protein that prevents DNA resection at stalled replication forks, highlighting its role in protecting the genome from damage during replication stress.

The paper identifies Syndecan-1 as a specific cerebrospinal fluid biomarker for multiple sclerosis, improving diagnostic and prognostic accuracy compared to existing markers.