Molecular BiologybioRxivPreprint
The Circadian Clock Controls Hepatic Stellate Cell Activation in Liver Fibrosis via a BMAL1/CK1ϵ/REV-ERBα/Transgelin Signaling Pathway.
Manuel Johanns, Alexandre Berthier, Jimmy Vandel…·Philippe Lefèbvre
This study identifies a circadian clock-controlled signaling pathway that drives hepatic stellate cell activation in liver fibrosis, offering potential drug targets and a basis for chronotherapeutic strategies.
DOI 10.1101/2025.09.12.675813