A cold-adapted Cas9 nuclease from the deep ocean
Alba Olaso Llorca, Francesco Colizzi, Gerard Mingarro, Pablo Sánchez, Carlos Sánchez-Bolaños, Constantino Andres Molina, Andrea Martinez-Cazorla, Rafael Serrano-Durán, Tomas Urbaitis, Natalia Rodrigo Melero, Albert Bosch, Maria Magallon-Mosella, Mark Margitfalvi, Migle Stitilyte, Carlo Carolis, , Julián Cerón
This paper characterizes DO1Cas9, a cold-adapted Cas9 nuclease from the deep ocean, showing improved activity under cold conditions and broader organismal applicability.
bioRxiv · Oct 16, 2026 · PreprintGenetics