Julián Cerón

This paper characterizes DO1Cas9, a cold-adapted Cas9 nuclease from the deep ocean, showing improved activity under cold conditions and broader organismal applicability.

The paper assesses PTEN variant functionality across species, showing context-dependent oncogenicity and interindividual variability using C. elegans and cell lines.

This study shows that ether lipid remodeling during neuronal differentiation prevents ferroptosis by balancing pro- and anti-ferroptotic effects through vinyl ether bonds.

The paper identifies a high abundance of CRISPR-Cas systems in deep ocean microbiomes, highlighting their diversity and potential for bioprospecting.

The paper shows that inactivating the NMD pathway suppresses the embryonic lethality of gsr-1 mutants in C. elegans by enabling the transsulfuration pathway to compensate for the loss of glutathione reductase function.

This study demonstrates the use of SpG and SpRY CRISPR-Cas9 variants in zebrafish and C. elegans for genome editing, showing improved accessibility to previously uneditable sites.

This study identifies a role for C. elegans I{kappa}B homologs in chromatin regulation, showing they bind histones, Polycomb proteins, and alter chromatin marks, suggesting ancestral I{kappa}B functions in development.

The paper uses CRISPR in C. elegans to mimic human splicing factor mutations causing retinitis pigmentosa, identifies disease modifiers, and screens for drugs, finding harmful compounds.

The paper introduces a cloning-free Nested CRISPR method for efficiently generating endogenous fluorescent reporters in C. elegans with high editing efficiency.