Asymmetrical Glyco-Engineering of Monoclonal Antibodies Provides Insights into α-Gal Immunogenicity
Gerlof P. Bosman, Anna M. Ehlers, Thomas Buckley, Justyna M. Dobruchowska, Javier Sastre Toraño, Arthur E. H. Bentlage, André C. Knulst, Gestur Vidarsson, Geert‐Jan Boons
This paper develops an enzymatic platform to synthesize diverse mAb glycoforms and uses them to study α-Gal immunogenicity and FcγR binding.
bioRxiv · Oct 27, 2026 · PreprintBiochemistry