Tatiana M. Shamorkina

Cetacean coronavirus spikes highlight S glycoprotein structural plasticity

This study presents cryo-EM structures of cetacean coronavirus S proteins, revealing unique structural features and glycosylation patterns that highlight structural plasticity and host adaptation.

Host cell remodeling via cyclin dependent kinases drives Ebola virus replication and transcription

This study identifies cyclin-dependent kinases as key drivers of Ebola virus replication and transcription through proteomic analysis of host cell remodeling.

Foamy microglia link oxylipins to disease progression in multiple sclerosis

The paper identifies foamy microglia as contributors to disease progression in secondary progressive MS, linking oxylipins to lesion expansion and proposing monoacylglycerol lipase as a therapeutic target.

Deep Coverage and Extended Sequence Reads Obtained with a Single Archaeal Protease Expedite de novo Protein Sequencing by Mass Spectrometry

This paper introduces HTA-proteases for de novo antibody sequencing, achieving higher peptide read coverage and accuracy compared to trypsin or chymotrypsin.

Proteolytic activity of surface exposed HtrA determines its expression level and is needed to survive acidic conditions in Clostridioides difficile

This study shows that HtrA proteolytic activity affects its expression level and is necessary for C. difficile survival under acidic conditions.

Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins

The paper demonstrates that fully glycosylated trimeric RBD proteins of SARS-CoV-2 bind more effectively to ACE2 compared to monomeric or immaturely glycosylated variants.