Bart L. Haagmans

The paper characterizes the pathogenicity of a newly emerged Andes virus (ANDV2026) in hamsters, showing high virulence, airborne shedding, and immune responses not previously described.

The paper compares SARS-CoV-2 antigenicity across assays and in human and animal model sera, finding similar immunodominance patterns and antigenic maps but differences in titer magnitude and assay-specific fold change.

The paper uses CRISPR/Cas9 to generate mutant intestinal organoids and identifies TMPRSS2 as a critical host factor for multiple coronaviruses.

The paper demonstrates that fully glycosylated trimeric RBD proteins of SARS-CoV-2 bind more effectively to ACE2 compared to monomeric or immaturely glycosylated variants.