Reconstruction of the human nigrostriatal pathway in vitro reveals target-dependent dopamine neuron maturation
Sara Corsi, Edoardo Sozzi, Andreas Bruzelius, Giorgio Scordo, German Ramos Passarello, Clara Zannino, Samuel T. da S. Maraschin, Surangrat Thongkorn, Arto Heiskanen, Janko Kajtez, Jenny Emnéus, Malin Parmar
The paper introduces a human stem cell-based model of the nigrostriatal pathway that mimics in vivo connectivity and reveals target-dependent dopamine neuron maturation.
The EMBO Journal · Oct 28, 2026Peer-reviewedNeuroscience