Andreas Bruzelius

Transient matrix remodeling during direct cell-fate reprogramming enables self-assembly of dense neuronal niches

This paper describes a method to generate dense neuronal microcultures by combining fibroblast reprogramming with matrix remodeling in collagen microgels.

Reconstruction of the human nigrostriatal pathway in vitro reveals target-dependent dopamine neuron maturation

The paper introduces a human stem cell-based model of the nigrostriatal pathway that mimics in vivo connectivity and reveals target-dependent dopamine neuron maturation.

Cografting strategies uncover cell type dependent regulation of dopamine neuron specification and functional maturation in a pre clinical model of Parkinson`s Disease

This study investigates how co-grafting strategies influence dopamine neuron specification and maturation in a Parkinson's disease model, identifying key transcription factors involved in the process.

Long-lasting structural and functional maturation in transplanted human neurons reprogrammed from glial progenitor cells

This study shows human neurons reprogrammed from glial progenitor cells survive and mature functionally in immunodeficient mice for up to 10 months.

Non-neuronal, TGF-β- extracellular matrix restructuring promotes neurodegeneration in a PSP-Richardson syndrome model

The paper identifies TGF-β-driven extracellular matrix remodeling in vascular leptomeningeal-like cells as a driver of neurodegeneration in PSP-RS, showing therapeutic potential through pharmacological inhibition.

Injectable 3D microcultures enable intracerebral transplantation of mature neurons directly reprogrammed from patient fibroblasts

This study develops a 3D microculture method to generate mature dopamine neurons from patient fibroblasts, which can be transplanted into a Parkinson's disease rat model to form functional neuron grafts.

Efficient generation of human oligodendrocyte grafts that restore myelin in adult human brain tissue

This study develops a method to efficiently generate human oligodendrocytes from induced pluripotent stem cells, which can form functional myelinating grafts in adult human brain tissue.

Generating human parvalbumin interneurons through 3D glia reprogramming

This paper describes a method to generate human parvalbumin interneurons from glial precursor cells using direct reprogramming and identifies a distinct transcriptional profile and reprogramming trajectory.