TET2-mutant clonal hematopoiesis prevents T-cell exhaustion and suppresses cancer metastasis
Ai Nhan Thi Le, Manabu Fujisawa, Giacomo Campo, Yen Thi Minh Nguyen, Tran Bich Nguyen, Sakurako Suma, Yasuhito Suehara, Fumihito Miura, Hiromitsu Araki, Kenichi Makishima, Tatsuhiro Sakamoto, Mizuho Nakayama, Masanobu Oshima, Miwako Kakiuchi, Shumpei Ishikawa, , Mamiko Sakata‐Yanagimoto
The paper shows TET2-mutant clonal hematopoiesis reduces cancer metastasis by preventing T-cell exhaustion through DNA methylation changes.
bioRxiv · Mar 11, 2026 · PreprintImmunology