Shumpei Ishikawa

The paper shows TET2-mutant clonal hematopoiesis reduces cancer metastasis by preventing T-cell exhaustion through DNA methylation changes.

This study identifies a transcriptomic signature predicting CD8+ T cell clone expansion rates and shows LAG-3 blockade reactivates this signature to re-expand contracted clones in tumors.

The paper introduces SpatialKNife, a toolkit for analyzing single-cell spatial omics data to estimate spatiotemporal pathological mechanisms in microenvironments.

This study uses single-cell RNA sequencing to create a large cell atlas of the human stomach, revealing new insights into cell diversity and developmental features, including potential stem cell markers and fibroblast distribution patterns in gastric and metaplastic mucosa.

Viola extracts biologically meaningful structural variant signatures from cancer data and provides tools for custom classification and annotation.

This study uses supervised machine learning to classify BCR/Ig sequences from normal and tumor tissues, finding distinct sequence-level features between the two environments.