CIP2A Mediates the Recruitment of the SLX4-MUS81-XPF Tri-Nuclease Complex in Mitosis and Protects Against Replication Stress
Alice Meroni, Annica Pellizzari, Nathalie Varisco, Francesco Leone, Giada Greco, Andrea Hänel, Pascale Brasier-Lutz, Isabell Witzel, Alessandro A. Sartori, Manuel Stucki
This paper shows CIP2A recruits the SMX tri-nuclease complex to manage under-replicated DNA during mitosis, preventing chromosome segregation errors in HRD cancers.
EMBO Reports · May 26, 2026Peer-reviewedCell Biology