Reconstructing physiological oxygen gradients reveals the role of hypoxia in colon epithelial organization
Jiaquan Yu, Chuyi Chen, Felicia H. Rodriguez, Gianfranco L. Yee, Isabella Yunfei Zeng, Yi Yang, Elizabeth K. Benitez, Karuna Ganesh, Scott R. Manalis
The paper quantifies oxygen gradients in the intestine and recreates them ex vivo to study hypoxia's role in epithelial organization.
bioRxiv · Dec 19, 2025 · PreprintBioengineering