Sarah M. Duquette

Lymph node resident memory T cells retain effector capabilities by evading lung resident memory dysfunction.

This study identifies lymph node resident memory T cells (LNRM) as a distinct subset with unique effector capabilities compared to lung resident memory T cells and central memory T cells.

Integrating Single-Cell Biophysical and Transcriptomic Features to Resolve Functional Heterogeneity in Mantle Cell Lymphoma

This study integrates single-cell biophysical and transcriptomic data to identify clinically relevant phenotypes in mantle cell lymphoma, linking biophysical properties to gene expression and drug response.

Measuring single-cell density with high throughput enables dynamic profiling of immune cell and drug response from patient samples

The paper develops a high-throughput method to measure single-cell density and applies it to study immune cell states and drug response in patient samples.

Mechanoimmunological Control of Metastatic Site Selection

This study shows how cancer cell stiffness, influenced by environmental rigidity, affects immune response and metastatic site selection in mice and patients.

Buoyant mass reveals distinct T cell states predictive of checkpoint response

The paper uses buoyant mass to identify distinct T cell states that predict response to immune checkpoint therapy in melanoma patients.

Plasma membrane folding enables constant surface area-to-volume ratio in growing mammalian cells

The paper shows that mammalian cells maintain a constant surface area-to-volume ratio as they grow by increasing plasma membrane folding.