Orthogonal resistance mechanisms of classical- and induced-proximity inhibitors
Manuel L. Merz, Karishma Kailass, Rajaiah Pergu, Kien Tran, Kritika Gupta, Zachary C. Severance, Sameek Singh, Vedagopuram Sreekanth, Benjamin K. Law, Gideon Rosenblatt, Rohil Dhaliwal, Amit Choudhary
This study shows induced-proximity inhibitors have orthogonal resistance mechanisms to classical inhibitors, using KRAS as a model system.
bioRxiv · May 10, 2025 · PreprintBiochemistry