Author

Karishma Kailass

Broad InstituteORCID 0009-0003-7052-490XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:protein design· 2 Assay:CRISPR screen· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Amit ChoudharyiD· 3 shared Vedagopuram SreekanthiD· 3 shared Chaiheon Lee· 2 shared Kien TraniD· 2 shared Rajaiah PerguiD· 2 shared Rohil DhaliwaliD· 2 shared Sameek SinghiD· 2 shared Santosh Kumar ChaudharyiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersSynthetic Biology

Amit ChoudharyORCID

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3 papers

Recent·Most cited

Synthetic BiologyProceedings of the National Academy of SciencesPeer-reviewedMay 26, 2026

Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells

Andrew L. Sabol, Amanuella A. Mengiste, Prashant Singh…·Matthew D. Shoulders

This paper develops CRISPR-MACE, a platform for continuous directed evolution of CRISPR-Cas9 in human cells, generating variants with enhanced DNA binding and resistance to AcrIIA4.

1 citation

humanCRISPR screen

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Synthetic BiologybioRxivPreprintFeb 21, 2026

A Scalable Design for Proximity-Inducing Molecules

Endri Karaj, Varsha Venkatarangan, Shaimaa H. Sindi…·Amit Choudhary

This paper introduces GRIPs, a scalable platform for PTM editing using chimeric molecules, demonstrating functionality in multiple systems and confirming specificity through proteomics.

3 citations

proteomicsexperimental assay

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BiochemistrybioRxivPreprintMay 10, 2025

Orthogonal resistance mechanisms of classical- and induced-proximity inhibitors

Manuel L. Merz, Karishma Kailass, Rajaiah Pergu…·Amit Choudhary

This study shows induced-proximity inhibitors have orthogonal resistance mechanisms to classical inhibitors, using KRAS as a model system.

2 citations

experimental assay

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