Author

Kien Tran

Broad InstituteORCID 0000-0002-2018-3591Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Amit ChoudharyiD· 3 shared Rajaiah PerguiD· 3 shared Sameek SinghiD· 3 shared Vedagopuram SreekanthiD· 3 shared Junya KawaiiD· 2 shared Karishma KailassiD· 2 shared Rohil DhaliwaliD· 2 shared Surached SiriwongsupiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Amit ChoudharyORCID

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Author profile →

3 papers

Recent·Most cited

A Scalable Design for Proximity-Inducing Molecules

Endri Karaj, Varsha Venkatarangan, Shaimaa H. Sindi, Surached Siriwongsup, Chaiheon Lee, Rajaiah Pergu, Vedagopuram Sreekanth, Karishma Kailass, Kien Tran, Prashant Kumar Singh, Sameek Singh, Junya Kawai, Jeffrey E. Fung, Mahilet Tefera, Rohil Dhaliwal, , Amit Choudhary

This paper introduces GRIPs, a scalable platform for PTM editing using chimeric molecules, demonstrating functionality in multiple systems and confirming specificity through proteomics.

bioRxiv · Feb 21, 2026 · PreprintSynthetic Biology

Phosphorylation-inducing molecules for regulating dynamic cellular processes

Rajaiah Pergu, Vedagopuram Sreekanth, Praveen Kokkonda, Sophia Lai, Praveen Kumar Tiwari, Sameek Singh, Junya Kawai, Santanu Singha, Wenzhi Tian, Vikram Thimaradka, Surached Siriwongsup, Kien Tran, Amit Choudhary

This paper introduces an AMPK PHICS platform that enables controlled protein phosphorylation under physiological conditions, demonstrating its utility in regulating oncogenic signaling and phase separation.

Journal of the American Chemical Society · Jul 14, 2025Peer-reviewedBiochemistry

Orthogonal resistance mechanisms of classical- and induced-proximity inhibitors

Manuel L. Merz, Karishma Kailass, Rajaiah Pergu, Kien Tran, Kritika Gupta, Zachary C. Severance, Sameek Singh, Vedagopuram Sreekanth, Benjamin K. Law, Gideon Rosenblatt, Rohil Dhaliwal, Amit Choudhary

This study shows induced-proximity inhibitors have orthogonal resistance mechanisms to classical inhibitors, using KRAS as a model system.

bioRxiv · May 10, 2025 · PreprintBiochemistry