Author

Manuel L. Merz

Broad InstituteORCID 0000-0001-7986-890XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Amit ChoudharyiD· 2 shared Rajaiah PerguiD· 2 shared Rohil DhaliwaliD· 2 shared Sameek SinghiD· 2 shared Zachary C. SeveranceiD· 2 shared Arghya DebiD· 1 shared Benjamin K. Law· 1 shared Brian B. LiauiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersSynthetic Biology

Amit ChoudharyORCID

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2 papers

Recent·Most cited

Synthetic BiologyACS Central SciencePeer-reviewedApr 9, 2026

Proximity-induced rewiring of oncogenic kinase triggers apoptosis

Manuel L. Merz, Veronika M. Shoba, Rajaiah Pergu…·Amit Choudhary

This paper develops a small molecule, BRD8833, that induces BCR-ABL phosphorylation to disrupt its active site electric field, leading to loss of hyperactivity and apoptosis in BCR-ABL-dependent cancer cells.

1 citation

humanexperimental assay

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BiochemistrybioRxivPreprintMay 10, 2025

Orthogonal resistance mechanisms of classical- and induced-proximity inhibitors

Manuel L. Merz, Karishma Kailass, Rajaiah Pergu…·Amit Choudhary

This study shows induced-proximity inhibitors have orthogonal resistance mechanisms to classical inhibitors, using KRAS as a model system.

2 citations

experimental assay

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