Myt Transcription Factors prevent stress-response gene over-activation to enable postnatal pancreatic β cell proliferation and function
Ruiying Hu, Emily M. Walker, Yanwen Xu, Chen Lu Huang, Chen Weng, Gillian E. Erickson, Anastasia Golovin, Xiaodun Yang, Marcella Brissova, Appakalai N. Balamurugan, Christopher V.E. Wright, Yan Li, Roland W. Stein, Guoqiang Gu
This study shows that Myt transcription factors prevent over-activation of stress-response genes in pancreatic β cells, maintaining their function and survival.
bioRxiv · Sep 18, 2019 · PreprintDevelopmental Biology