Nuclear acetyl-CoA production by acetyl-CoA synthetase enables dynamic histone acetylation and gene expression in Plasmodium falciparum
Reginald Florian Akossi, Patty B. Chen, Jennifer Schwarz, Florent Dingli, Yoshiki Yamaryo‐Botté, Catarina Rosa, Giulia Litta Modignani, Damarys Loew, Cyrille Y. Botté, Sebastian Baumgarten, Jessica M. Bryant
This study shows that acetyl-CoA synthetase (ACAS) in Plasmodium falciparum is essential for nuclear histone acetylation, which regulates gene expression and the transcriptional cycle during the parasite's life cycle.
bioRxiv · Jul 17, 2026 · PreprintMolecular Biology