Jennifer Schwarz

Nuclear acetyl-CoA production by acetyl-CoA synthetase enables dynamic histone acetylation and gene expression in Plasmodium falciparum

This study shows that acetyl-CoA synthetase (ACAS) in Plasmodium falciparum is essential for nuclear histone acetylation, which regulates gene expression and the transcriptional cycle during the parasite's life cycle.

An ancient monoaminergic signaling system coordinates contractility in a nerveless sponge

This study identifies an ancient monoaminergic system in sponges that coordinates contractility through tryptamine signaling, predating neurons.

High-throughput peptide-centric local stability assay extends protein-ligand identification to membrane proteins, tissues, and bacteria

This paper introduces HT-PELSA, a high-throughput adaptation of a peptide-centric local stability assay, enabling sensitive protein-ligand profiling in diverse biological samples.

Integrative Multi-Omics Identifies CDK1 as a Key Signaling Regulator of CD4+ T Cell Effector Function

This study identifies CDK1 as a key regulator of CD4+ T cell effector function through integrative multi-omics analysis, showing its role in linking phosphorylation to gene regulation and immune traits.

Targeting the paralog protein for degradation accounts for the opposite roles of NRBP1 and NRBP2 in regulating LINE1 retrotransposition

The paper shows NRBP1 and NRBP2 oppositely regulate LINE1 retrotransposition through proteasome-mediated degradation of NRBP1 by NRBP2, with NRBP2's regulatory function evolving later.

Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progression

This paper uses time-resolved multi-omics analysis of kidney fibrosis to identify novel mechanisms and validate transcription factors involved in collagen deposition.

A multi-omics and cell type-specific characterization of the ventral striatum in human cocaine use disorder

This study characterizes molecular changes in the ventral striatum of individuals with cocaine use disorder using multi-omics and single-cell approaches, identifying perturbations in metabolic pathways and cell-type-specific alterations.

Image-based screens identify regulators of endogenous Dvl2 biomolecular condensates

The paper identifies regulators of Dvl2 biomolecular condensates using image-based screens and phosphoproteomics, finding CK1δ/ε inhibition blocks condensate formation and modulates Wnt signaling.

The structural mechanism of MCIA complex assembly links mitochondrial redox pathways

This study reveals the structural mechanism of MCIA complex assembly, showing how ECSIT and ACAD9 interact to facilitate Complex I biogenesis and links ECSIT phosphorylation to Alzheimer's disease pathology.

Pseudokinase HPO-11 inhibits nonsense-mediated decay to ensure genome stability in C. elegans

This study identifies HPO-11 as a pseudokinase that inhibits nonsense-mediated decay (NMD) to maintain genome stability in C. elegans by preventing R-loop accumulation and DNA damage.