Cyrille Y. Botté

Toxoplasma gondii Fatty Acid Elongases are Important for Virulence and Persistence

This paper investigates the role of fatty acid elongases (FAE) in Toxoplasma gondii type II strains, showing their importance for virulence, persistence, and lipid metabolism under stress.

Nuclear acetyl-CoA production by acetyl-CoA synthetase enables dynamic histone acetylation and gene expression in Plasmodium falciparum

This study shows that acetyl-CoA synthetase (ACAS) in Plasmodium falciparum is essential for nuclear histone acetylation, which regulates gene expression and the transcriptional cycle during the parasite's life cycle.

A lipid droplet triacylglycerol lipase governs neutral lipids mobilization and differentiation of Trypanosoma brucei

This study identifies and characterizes TbPat, a triacylglycerol lipase in Trypanosoma brucei, showing its role in lipid mobilization and differentiation.

Cardiolipin constrains lipid unsaturation during anaerobic adaptation in Escherichia coli

This study investigates how cardiolipin influences lipid unsaturation and membrane function during anaerobic adaptation in E. coli, revealing its role in optimizing membrane protein function.

MMV687794 blocks Plasmodium falciparum invasion of red blood cells by targeting a Surface-associated Lipid-Interacting Rhoptry Protein, PfSLIRP

This study identifies MMV687794 as an inhibitor of Plasmodium falciparum RBC invasion by targeting PfSLIRP, a rhoptry protein involved in lipid metabolism and vacuole formation.

Plasmodium falciparum aquaglyceroporin (PfAQP) orchestrates glycerol-dependent lipid metabolism, membrane biogenesis, metabolomic flux, parasite growth and stress adaptation

This study identifies PfAQP's role in glycerol-dependent lipid metabolism, membrane biogenesis, and stress adaptation in Plasmodium falciparum through knockdown and metabolomic analyses.

Characterisation of Two Plasmodium Virulence Factors Important for Lipid Metabolism and Disease Progression In Vivo

This study identifies two Plasmodium virulence factors involved in lipid metabolism and disease progression by analyzing their function in vivo.

ORP5 controls the partitioning of phosphatidic acid between triacylglycerol and cardiolipin synthesis at mitochondria-ER-lipid droplet contact sites

This study identifies ORP5 as a key regulator of phosphatidic acid partitioning between triacylglycerol and cardiolipin synthesis at MAM-LD junctions, showing its role in balancing lipid metabolism and mitochondrial health.

A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium

This study identifies the SUN1-ALLAN complex as critical for coordinating nuclear envelope remodeling and bipartite MTOC segregation during rapid mitosis in Plasmodium male gametogenesis.

Nucleoside Diphosphate Kinases 1 and 2 regulate a protective liver response to a high-fat diet

This study shows that NME1/2 regulate liver response to high-fat diet by repressing de novo lipogenesis and activating protective gene expression through histone acetylation.