Connectomic and behavioral alterations in creatine transporter deficiency are partially normalized by gene therapy
Caterina Montani, Ludovica Iovino, Federica Di Vetta, Jean-Charles Rene’ Pasquin Mariani, A. Elizabeth de Guzman, Silvia Gini, Alberto Galbusera, Bianca D’Epifanio, Elsa Ghirardini, Sara Cornuti, Lorenzo Dadà, Elena Putignano, M. Alessandri, Giulia Vasirani, Sine Mandrup Bertozzi, , Alessandro Gozzi
This paper investigates brain network and behavioral changes in a mouse model of CTD and shows that perinatal gene therapy can partially reverse some symptoms but not all.
bioRxiv · Jan 12, 2024 · PreprintNeuroscience