Ludovica Iovino

This study identifies Ackr3 as a regulator of astrocyte-mediated synaptic removal in disease, showing its role in synapse engulfment and its upregulation in Alzheimer's disease.

This study shows that LRRK2-G2019S mutation in microglia increases nuclear ASC speck formation, indicating a primed inflammasome state linked to chronic neuroinflammation in Parkinson's disease.

This paper shows that the LRRK2 G2019S mutation reduces GABA-evoked currents and disrupts the excitatory/inhibitory balance in the striatum.

This study quantifies PAK6 and 14-3-3 gamma in plasma to assess their potential as biomarkers for diagnosing sporadic and LRRK2-linked Parkinson's disease.

This paper investigates brain network and behavioral changes in a mouse model of CTD and shows that perinatal gene therapy can partially reverse some symptoms but not all.

This study investigates the role of CLEC7A-positive microglia and dark microglia in a mouse model of Parkinson's disease with the LRRK2 G2019S mutation, revealing their association with cellular stress and pathology.

This study shows that the LRRK2 G2019S mutation impairs EAAT2 trafficking, leading to reduced glutamate clearance and potential neurodegeneration in Parkinson's disease.