Elena Putignano

This study shows that miR-29 regulates memory stability, synaptic gene expression, and DNA methylation in adult mouse hippocampus by modulating Dnmt3a levels.

This study investigates gut microbiota changes in CDKL5 deficiency disorder mouse models and shows that antibiotic treatment improves neurological outcomes and microglial function.

This paper investigates brain network and behavioral changes in a mouse model of CTD and shows that perinatal gene therapy can partially reverse some symptoms but not all.

The paper creates a comprehensive atlas of perineuronal net distribution and colocalization with parvalbumin cells in the adult mouse brain, revealing correlations with synaptic plasticity and circuit stability.

The paper identifies 14 biomarkers associated with cognitive improvement in a Slc6a8 knockout mouse model treated with DCE, linking them to proteins involved in CTD pathogenesis.

This study shows that mGluR5 positive-allosteric modulators correct synaptic and behavioural defects in a CDKL5 deficiency disorder mouse model and human patients.