A TAK1Cytokine Toxicity Checkpoint Controls Anti-Cancer Immunity
Tirta Mario Djajawi, Anne Huber, S. Rivera, Akash Srivaths, Maede Salehi, Gokhan Gunay, Chloe Gerak, Liam Neil, Oliver Ozaydin, Olivia Voulgaris, Aleen Al Halawani, Daire Gannon, Nooshin Khoshdoozmasouleh, Laura J. Jenkins, Kok Fei Chan, , Conor J. Kearney
This study identifies TAK1 as a cancer-intrinsic checkpoint that limits CD8+ T cell-mediated anti-cancer immunity by suppressing TNF and IFNγ-induced apoptosis, and shows that targeting TAK1 enhances anti-tumor responses.
bioRxiv · May 9, 2025 · PreprintCancer Biology