S. Rivera

An MLL-Independent Function of Menin Promotes Resistance to MAPK-Targeted Therapy

This study identifies Menin's MLL-independent role in promoting resistance to MAPK-targeted therapy in BRAF-mutant colorectal cancer.

INTS12 Bridges Integrator and NELF to Prevent the Release of Non-processive RNA Polymerase II Complexes

This paper identifies INTS12's role in stabilizing the Integrator-NELF complex to prevent the release of defective RNA Polymerase II complexes, showing its importance in transcription regulation and cellular toxicity.

Powerful read processing with matchbox

matchbox provides a flexible and scalable read processor for handling diverse sequencing tasks, demonstrating versatility in demultiplexing, restranding, CRISPR efficiency assessment, and haplotyping.

A TAK1Cytokine Toxicity Checkpoint Controls Anti-Cancer Immunity

This study identifies TAK1 as a cancer-intrinsic checkpoint that limits CD8+ T cell-mediated anti-cancer immunity by suppressing TNF and IFNγ-induced apoptosis, and shows that targeting TAK1 enhances anti-tumor responses.

GWAS and 3D chromatin mapping identifies multicancer risk genes associated with hormone-dependent cancers

The paper identifies 44 multi-cancer risk regions across four hormone-dependent cancers using GWAS and 3D chromatin mapping, annotating 53 candidate risk genes with potential therapeutic implications.