Author

Aleen Al Halawani

Walter and Eliza Hall Institute of Medical ResearchORCID 0009-0004-6786-5145Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

S. RiveraiD· 3 shared Stephin J. VervoortiD· 3 shared Akash Srivaths· 2 shared Anne Huber· 2 shared Bhupinder PaliD· 2 shared Chloe Gerak· 2 shared Conor J. KearneyiD· 2 shared John Martin MariadasoniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

S. RiveraORCID

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Author profile →

3 papers

Recent·Most cited

An MLL-Independent Function of Menin Promotes Resistance to MAPK-Targeted Therapy

Akash Srivaths, Aleen Al Halawani, Tirta Mario Djajawi, Anne Huber, Chloe Gerak, Laura J. Jenkins, Rebekah Crake, Kristen A. Needham, Biswadeep Sen, S. Rivera, Nooshin Khoshdoozmasouleh, Lisa Anna Mielke, Liam Neil, Bhupinder Pal, John Martin Mariadason, , Stephin J. Vervoort

This study identifies Menin's MLL-independent role in promoting resistance to MAPK-targeted therapy in BRAF-mutant colorectal cancer.

bioRxiv · Aug 26, 2026 · PreprintCancer Biology

INTS12 Bridges Integrator and NELF to Prevent the Release of Non-processive RNA Polymerase II Complexes

Laura Corso, S. Rivera, Aleen Al Halawani, Chloe A. N. Gerak, Dáire Gannon, Oliver Ozaydin, Mengbo Li, Kedhar Thyagarajan, Lukasz Niezabitowski, Ngee Kiat Chua, Winnie Tan, Susanne I. Wudy, Aoife McLysaght, Gordon K. Smyth, Shabih Shakeel, , Stephin J. Vervoort

This paper identifies INTS12's role in stabilizing the Integrator-NELF complex to prevent the release of defective RNA Polymerase II complexes, showing its importance in transcription regulation and cellular toxicity.

bioRxiv · Jan 17, 2026 · PreprintMolecular Biology

A TAK1Cytokine Toxicity Checkpoint Controls Anti-Cancer Immunity

Tirta Mario Djajawi, Anne Huber, S. Rivera, Akash Srivaths, Maede Salehi, Gokhan Gunay, Chloe Gerak, Liam Neil, Oliver Ozaydin, Olivia Voulgaris, Aleen Al Halawani, Daire Gannon, Nooshin Khoshdoozmasouleh, Laura J. Jenkins, Kok Fei Chan, , Conor J. Kearney

This study identifies TAK1 as a cancer-intrinsic checkpoint that limits CD8+ T cell-mediated anti-cancer immunity by suppressing TNF and IFNγ-induced apoptosis, and shows that targeting TAK1 enhances anti-tumor responses.

bioRxiv · May 9, 2025 · PreprintCancer Biology