Author

Conor J. Kearney

La Trobe UniversityORCID 0000-0002-9891-5078Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Bhupinder PaliD· 3 shared John Martin MariadasoniD· 3 shared Liam NeiliD· 3 shared Lisa Anna MielkeiD· 3 shared Stephin J. VervoortiD· 3 shared Akash Srivaths· 2 shared Aleen Al HalawaniiD· 2 shared Anne Huber· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

Bhupinder PalORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ICOS blockade alleviates immune suppression in breast tumor microenvironment

Shalini Guleria, Chamikara Liyanage, William J. Hutchison, Kurtis Treller, Liam Neil, Yingnan Gao, Belinda Jane Yeo, John Martin Mariadason, Conor J. Kearney, Lisa Anna Mielke, Axel Kallies, Sadanand Vodala, Robin L. Anderson, Delphine Mérino, Anthony T. Papenfuss, , Bhupinder Pal

This study shows that blocking ICOS reduces immune suppression in breast tumors by altering Treg and CD8 T cell dynamics, enhancing anti-tumor immunity.

bioRxiv · Oct 23, 2026 · PreprintCancer Biology

An MLL-Independent Function of Menin Promotes Resistance to MAPK-Targeted Therapy

Akash Srivaths, Aleen Al Halawani, Tirta Mario Djajawi, Anne Huber, Chloe Gerak, Laura J. Jenkins, Rebekah Crake, Kristen A. Needham, Biswadeep Sen, S. Rivera, Nooshin Khoshdoozmasouleh, Lisa Anna Mielke, Liam Neil, Bhupinder Pal, John Martin Mariadason, , Stephin J. Vervoort

This study identifies Menin's MLL-independent role in promoting resistance to MAPK-targeted therapy in BRAF-mutant colorectal cancer.

bioRxiv · Aug 26, 2026 · PreprintCancer Biology

A TAK1Cytokine Toxicity Checkpoint Controls Anti-Cancer Immunity

Tirta Mario Djajawi, Anne Huber, S. Rivera, Akash Srivaths, Maede Salehi, Gokhan Gunay, Chloe Gerak, Liam Neil, Oliver Ozaydin, Olivia Voulgaris, Aleen Al Halawani, Daire Gannon, Nooshin Khoshdoozmasouleh, Laura J. Jenkins, Kok Fei Chan, , Conor J. Kearney

This study identifies TAK1 as a cancer-intrinsic checkpoint that limits CD8+ T cell-mediated anti-cancer immunity by suppressing TNF and IFNγ-induced apoptosis, and shows that targeting TAK1 enhances anti-tumor responses.

bioRxiv · May 9, 2025 · PreprintCancer Biology

A PP2A-Integrator complex fine-tunes transcription by opposing CDK9

Stephin J. Vervoort, Sarah A. Welsh, Jennifer R. Devlin, Elisa Barbieri, Deborah A. Knight, Sarah R. Offley, Stefan Bjelosevic, Matteo Costacurta, Izabela Todorovski, Conor J. Kearney, Jarrod John Sandow, Zheng Fan, Benjamin J. Blyth, Victoria M. McLeod, Joseph H.A. Vissers, , Ricky W. Johnstone

The paper identifies a PP2A-Integrator complex that opposes CDK9 activity to regulate transcription and shows its therapeutic synergy in leukemia.

Cell · May 17, 2021Peer-reviewedGenomics