Exacerbation of neurodegeneration by a metabolically engineered bacterium in a mouse model of tauopathy
Wade K. Self, Prabal Sharma, Grace Gent, Megan E. Bosch, Yiyang Zhu, Noah Powell, Cansu Agca, Jason D. Ulrich, Jianxun Jim Song, Paul de Figueiredo, David M. Holtzman
This study shows that an engineered bacterium worsens neurodegeneration in a tauopathy mouse model by altering immune responses, while the unmodified strain has no effect.
bioRxiv · Oct 8, 2026 · PreprintNeuroscience