Author

Megan E. Bosch

Washington University in St. LouisORCID 0000-0003-1404-6870Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

David M. HoltzmaniD· 2 shared Jason D. UlrichiD· 2 shared Aishwarya NambiariD· 1 shared Bernd H. ZinselmeyeriD· 1 shared Brisa Lugo· 1 shared Cansu AgcaiD· 1 shared Fareeha SaadiiD· 1 shared Grace Gent· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

David M. HoltzmanORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 14, 2026

APOE4 reduction in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and associated vascular dysfunction

Fareeha Saadi, Yoonho Cho, Ilia V Katritch…·David M. Holtzman

This study shows that reducing APOE4 in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and improves vascular function in a mouse model.

DOI 10.64898/2026.10.02.756327

mouseexperimental assay

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NeurosciencebioRxivPreprintOct 8, 2026

Exacerbation of neurodegeneration by a metabolically engineered bacterium in a mouse model of tauopathy

Wade K. Self, Prabal Sharma, Grace Gent…·David M. Holtzman

This study shows that an engineered bacterium worsens neurodegeneration in a tauopathy mouse model by altering immune responses, while the unmodified strain has no effect.

DOI 10.64898/2026.09.28.755025

mouseproteomics

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