Paul de Figueiredo

Agent K automates the mapping of bacterial genomes to biosynthetic pathways and metabolite discovery using an agent-orchestrated framework with a large-language model.

Host-measured parts and inducible systems for Brucella melitensis ΔvjbR guided a modeled Cas9 kill-switch, which cut mouse liver bacterial burden by about 91% at 30 mg/kg doxycycline.

This paper develops a method to improve transformation efficiency in non-model Gram-negative bacteria by enhancing post-electroporation recovery.

This study shows that an engineered bacterium worsens neurodegeneration in a tauopathy mouse model by altering immune responses, while the unmodified strain has no effect.

This paper introduces a synthetic microbial therapy that enhances antitumor immunity across multiple cancer types in mice, showing durable responses and synergy with chemotherapy.

This paper develops iSTORM, a Salmonella-based immunotherapy that silences CMTM6 in PDAC tumors, enhancing T-cell function and tumor control while maintaining safety.

This paper introduces PERFECT PCR, a method that improves DNA data storage density and accuracy, achieving 94% of theoretical maximum storage density with significantly lower error rates.

PRISM isolates, quantifies, and characterizes bacteriophages without plating, recovering non-plaquing phages and improving titering accuracy.