Author

Prabal Sharma

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

David M. HoltzmaniD· 2 shared Jason D. UlrichiD· 2 shared Cansu AgcaiD· 1 shared Carisa ZengiD· 1 shared Grace Gent· 1 shared Hao HuiD· 1 shared Hong Jiang· 1 shared Jianxun Jim SongiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersNeuroscience

David M. HoltzmanORCID

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2 papers

Recent·Most cited

Exacerbation of neurodegeneration by a metabolically engineered bacterium in a mouse model of tauopathy

Wade K. Self, Prabal Sharma, Grace Gent, Megan E. Bosch, Yiyang Zhu, Noah Powell, Cansu Agca, Jason D. Ulrich, Jianxun Jim Song, Paul de Figueiredo, David M. Holtzman

This study shows that an engineered bacterium worsens neurodegeneration in a tauopathy mouse model by altering immune responses, while the unmodified strain has no effect.

bioRxiv · Oct 8, 2026 · PreprintNeuroscience

CD8+ T cells are primed by cDC1 and exacerbate tau-mediated neurodegeneration

Hao Hu, Peter Bor‐Chian Lin, Carisa Zeng, Prabal Sharma, Yongyi Li, Hong Jiang, Jonathan Nulman, Ray A. Ohara, Tong Wu, Shasha Li, Wayne M. Yokoyama, Maxim N. Artyomov, KENNETH M. M. MURPHY, Jason D. Ulrich, David M. Holtzman

This study shows that cDC1 cells prime CD8+ T cells, which then exacerbate tau-mediated neurodegeneration in mice.

bioRxiv · Mar 1, 2026 · PreprintNeuroscience