Author

Cansu Agca

University of MissouriORCID 0000-0001-6641-7448Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:proteomics· 1 Approach:simulation· 1

Frequent Co-Authors

Paul de FigueiredoiD· 3 shared Chelsea Y. HuiD· 2 shared Noah PowelliD· 2 shared Yeonhwee JeongiD· 2 shared David M. HoltzmaniD· 1 shared Grace Gent· 1 shared Hari R. NamboothiriiD· 1 shared Jason D. UlrichiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersSynthetic Biology

Paul de FigueiredoORCID

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3 papers

Recent·Most cited

Integrating Genetic Domestication and Model-Guided Kill-Switch Engineering in a Non-Model Bacterial Therapeutic

Yeonhwee Jeong, Hari R. Namboothiri, Oluwatola Femi-Olatunji, Paul de Figueiredo, Cansu Agca, Chelsea Y. Hu

Host-measured parts and inducible systems for Brucella melitensis ΔvjbR guided a modeled Cas9 kill-switch, which cut mouse liver bacterial burden by about 91% at 30 mg/kg doxycycline.

bioRxiv · Oct 20, 2026 · PreprintSynthetic Biology✦ In-depth digest

Restoring post-electroporation envelope integrity enables efficient spheroplast transformation of non-model Gram-negative bacteria

Yeonhwee Jeong, Kimia Hadidian, Noah Powell, Cansu Agca, Paul de Figueiredo, Chelsea Y. Hu

This paper develops a method to improve transformation efficiency in non-model Gram-negative bacteria by enhancing post-electroporation recovery.

bioRxiv · Oct 20, 2026 · PreprintSynthetic Biology

Exacerbation of neurodegeneration by a metabolically engineered bacterium in a mouse model of tauopathy

Wade K. Self, Prabal Sharma, Grace Gent, Megan E. Bosch, Yiyang Zhu, Noah Powell, Cansu Agca, Jason D. Ulrich, Jianxun Jim Song, Paul de Figueiredo, David M. Holtzman

This study shows that an engineered bacterium worsens neurodegeneration in a tauopathy mouse model by altering immune responses, while the unmodified strain has no effect.

bioRxiv · Oct 8, 2026 · PreprintNeuroscience