The E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters
Pragya Parashara, Lei Gao, Alyssa Riglos, Dorothy Lartey, Sonia B. Sidhu, Tessa Marks, Chris E. Williams, Grace Siauw, Kai-Jing Lee, Anna I. L. Ostrem, Christian Siebold, Michael E. Riffle, Maia Kinnebrew, Teresa M. Gunn, Jennifer H. Kong
This study identifies ATRN and ATRNL1 as transmembrane adapters that recruit MGRN1 to ubiquitinate and degrade MC1R and MC4R, expanding the known substrate repertoire of MGRN1.
Journal of Cell Science · Nov 3, 2025Peer-reviewedCell Biology