A cryptic pocket allosterically modulates oligosaccharide binding to DC-SIGN
Jonathan Lefèbre, Maurice Besch, Marcelo Daniel Gamarra, Jan-Oliver Kapp-Joswig, Annika Balke, Stevan Aleksić, Henry Flatau, Gregor Suchy, Elena Georgieva, Patrick Scheerer, Bettina G. Keller, Carlos Pablo Modenutti, Christoph Rademacher
The paper identifies a cryptic allosteric pocket in DC-SIGN that modulates oligosaccharide binding through conformational changes and residue mutations.
JACS Au · Jan 20, 2026Peer-reviewedBiochemistry