Author
Humboldt-Universität zu BerlinORCID 0000-0001-5028-2075Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Jonathan Lefèbre, Maurice Besch, Marcelo Daniel Gamarra…·Christoph Rademacher
The paper identifies a cryptic allosteric pocket in DC-SIGN that modulates oligosaccharide binding through conformational changes and residue mutations.
Lukas Hinkelmann, Mariam Brehm, Victor Wumbor-Apin Kumbol…·Seija Lehnardt
This study shows that murine TLR8 is a functional nucleic acid sensor, responding to synthetic and endogenous ligands and restoring TLR7-dependent transcriptional programs in vivo.
Shannon Bareesel, Thomas J. Böddeker, Willem Bintig…·Britta Johanna Eickholt
This study identifies PLPPR3 condensates as actin sinks that locally boost monomer concentrations, promoting actin polymerization and filopodia formation in neurons.
Iqra Sohail, Suli‐Anne Laurin, Gunnar Kleinau…·Heike Biebermann
This study shows that MRAP2 modifies MC4R signaling and oligomerization, enhancing G protein signaling while reducing beta-arrestin2 recruitment and receptor internalization.
Deana Haxhiraj, Benno Kuropka, Eva Brencher…·Christian Freund
This study identifies DHHC20 interaction partners in T cells, showing it interacts with Gsβ1γ2 and suggests a model for its role in palmitoylation.
Paul Dembny, Andrew G. Newman, Manvendra Singh…·Seija Lehnardt
This study shows HERV-K(HML-2) RNA activates TLR8 and Tlr7, causing neurodegeneration in mice and correlating with AD in humans.